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15:40 - 16:10
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Paper No. 2015-SAT-S0605-I001
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Invited Speaker:
Manabu Tanifuji
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Functional OCT as a technique to visual functional structures in the brain
Visualization of light reflection changes reveals spatial patterns of neural activity in in vivo brain tissues. We applied this technique to visualize activity patterns in retina (FRG: functional retinography), and obtained clear evidence that the sources of light reflection changes include the change in light scattering elicited by neural activation (1). Optical coherence tomography (OCT) is a 3D structural imaging technique using light interference (2). Since OCT detects a coherent component of light, it is highly sensitive to light scattering. Thus, OCT could be used to detect neural activity patterns in 3D by extracting neural- activity-induced modulation of OCT signals. We proposed this idea in 2007 and named it functional OCT (3). Here, applying this technique to mammalian primary visual cortex, and found a novel functional structure, singularity string, that potentially revise classical concept of columnar functional architecture in primary visual cortex.
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16:10 - 16:25
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Paper No. 2015-SAT-S0605-O001
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| Dan JI
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Evaluation of scattering features for tissue segmentation using an OCT with submicron resolution
This study aims to use a Mirau-based full-field optical coherence tomography with submicron resolution to scan surgical specimens and use automated algorithms to determine if melanoma positive margins were left behind. The OCT images were tested against H&E stain. Results of automated interpretation can reach 86.38% sensitivity and 81.89% specificity.
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16:25 - 16:40
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Paper No. 2015-SAT-S0605-O002
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| Ding-Zhang Tsai
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MicroRNA Biosensing using Telecommunication Wavelength Interrogated Waveguide-Coupled Surface Plasmon Resonance
The surface plasmon resonance detection for very small molecules, such as cancer diagnosis microRNA, is very challenging. Due to the high precision and stability control in optical fiber communications, the telecommunication wavelength was interrogated to detect several-nanometer long microRNA for high sensitivity and high resolution through waveguide-coupled surface plasmon resonance.
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16:40 - 16:55
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Paper No. 2015-SAT-S0605-O003
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| Liang-Yu Chen
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Spectrally Constrained Diffuse Optical Imaging
Diffuse optical imaging is showing promise for breast cancer detection by estimating chromophore concentrations of breast tissue. In this study, a spectrally constrained image reconstruction algorithm is presented for the estimation of chromophore concentration directly, including oxy-hemoglobin, deoxy-hemoglobin concentrations, and water fraction. This leads to functional medical imaging.
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16:55 - 17:10
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Paper No. 2015-SAT-S0605-O004
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| Yi-Chang Wu
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Intracellular stiffness quantifies epithelial-mesenchymal transition Progression
Twist1 mediated RAC1 activation induces epithelial-mesenchymal transition (EMT) progression. In this study, we investigated the effect of Twist1-let-7i-RAC1 signal axis on intracellular stiffness and migration of cancer cells. Our findings reveal that the inhibition of Twist1-let-7i-RAC1 signal axis leads to an increase in stiffness and a reduction in migration.
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